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Dr. John J. Trimble

John Trimble

Title: Assistant Professor of Biology
School: Sciences
Academic Department: Biology
Phone: 814-472-3319
E-mail: jtrimble@francis.edu
Office Location: Science Center 113

Education

  • B.S., Saint Francis College
  • Ph.D., The Pennsylvania State University
  • Post-Doctoral Research, Harvard Medical School

Biography

Courses Taught

Courses Taught Include

  • BIOL 105 - Human Biology
  • BIOL 111 - Biology I
  • BIOL 214 - Clinical Microbiology
  • BIOL 214L - Clinical Microbiology Lab
  • BIOL 302 - General Microbiology
  • BIOL 302 - General Microbiology Lab
  • BIOL 401 - Cell and Molecular Biology
  • BIOL 401L - Cell and Molecular Biology
  • BIOL 402 - Evolution
  • BIOL 405 - Biochemistry
  • BIOL 412 - Virology
  • BIOL 430 - Advanced Molecular Methods
  • CORE 102 - Colloquium Courses
  • (topics include: AIDS, Risk, Crime and Punishment, Aging in America, and The Ethical, Legal, and Social Implications of the Human Genome Project)
Research

Research interests

Fluoroquinolone-induced tendopathy

"These are exciting times to be a student of biology. Biotechnology and molecular biology techniques are transforming medicine, therapies for cancer, diagnostics for genetic and infectious diseases, and practically every field of biology from agriculture to zoology. My interest is to train our students, intellectually and with practical skills, to take part in these burgeoning fields of employment and advanced study."

Current undergraduate research projects in

  • Sequencing of 16S ribosomal DNA from bacterial symbiotes of marine sponges

Past undergraduate research projects in

  • RAPD Analysis of Genetic Diversity in an Endemic Freshwater Mollusk, "Ferrissia rivularis"
  • The Effect of Fluoroquinolone Therapy on Achilles Tendon Strength in Rats
  • Oral Chromium Therapy for Type 2 Diabetes in Zucker Fatty Diabetic Rats
  • Investigating Probiotic Product Claims and Antibacterial Pen Product Claims
  • The Chemoattraction of Sperm in C-fern Reproduction
  • Developing a Laboratory Exercise in Forensic Analysis of Blood Evidence
Professional Activity

Previous Positions

  • 2001-2004, Visiting Associate Professor (Summers and Sabbatical), Pennsylvania State University, Civil and Environmental Engineering
  • 1996-1999, Visiting Scientist (Summers), Pennsylvania State University, Biochemistry and Molecular Biology
  • 1990-1994, Research Scientist, Bristol Myers-Squibb Pharmaceutical Research Institute, Anti-Infective Virology, HIV Drug Discovery

Professional Societies and Affiliations

  • Saint Francis University Honor Society
  • American Society for Microbiology (ASM) (since 1980)
  • Allegheny Branch of ASM (since 1995)
  • American Association for the Advancement of Science (AAAS) (since 1983)
  • Faculty for the 21st Century (F21) in Project Kaleidoscope (since 2001)
  • Council for Undergraduate Research (CUR) (since 1997)
Publications

Publications

  • Steinberg, Lisa M., Trimble, John J., Logan, Bruce E., Enzymes Responsible for Chlorate Reduction By Pseudomonas Sp. Are Different From Those Used for Perchlorate Reduction By Azospira Sp., FEMS Microbiology Letters, www.fems-microbiology.org, Elisevier, 247, 153-159, 2005
  • Jianlin Xu, John J. Trimble, Lisa Steinberg, and Bruce E. Logan, Chlorate and nitrate reduction pathways are separately induced in the perchlorate-respiring bacterium Dechlorosoma sp. KJ and the chlorate-respiring bacterium Pseudomonas sp. PDA, Water Research, 38, 673-680, January 2004
  • Yakhnin AV, Trimble JJ, Chiaro CR, Babitzke P, Effects of mutations in the L-tryptophan binding pocket of the Trp RNA-binding attenuation protein of Bacillus subtilis, Journal of Biological Chemistry, 275(6), 4519-24, February 2000
  • Trimble JJ, Salkowitz JR, and Kestler, HW, Animal Models for AIDS Pathogenesis, Advances in Pharmacology, 49, 479-514, 2000
  • Lee H, Trimble JJ, Yoon DW, Regier D, Desrosiers RC, Jung JU, Genetic variation of herpesvirus saimiri subgroup A transforming protein and its association with cellular src, Journal of Virology, 71(5), 3817-25, May 1997
  • Qian-Cutrone J, Huang S, Trimble J, Li H, Lin P-F, Alam M, Klohr S and Kadow K, Niruriside, a New HIV REV/RRE Binding Inhibitor from Phyllanthus niruri, Journal of Natural Products, 59, 196-199, 1996
  • Lin PF, Samanta H, Rose RE, Patick AK, Trimble J, Bechtold CM, Revie DR, Khan NC, Federici ME, Li H, et al, Genotypic and phenotypic analysis of human immunodeficiency virus type 1 isolates from patients on prolonged stavudine therapy, Journal of Infectious Diseases, 170(5), 1157-64, November 1994
  • Samanta H, Rose R, Patick A, Bechtold CM, Trimble JJ, Li H, Colonno R and Lin, P-F, Characterization of a mutant HIV-1 reverse transcriptase resistant to a nonnucleoside inhibitor (R82150), Antiviral Chemistry and Chemotherapy, 5, 278-281, 1994
  • Alam M, Bechtold CM, Patick AK, Skoog MT, Gant TG, Colonno RJ, Meyers AI, Li H, Trimble J, Lin PF, Substituted naphthalenones as a new structural class of HIV-1 reverse transcriptase inhibitors, Antiviral Research, 22(2-3), 131-41, October 1993
  • Jung JU, Trimble JJ, King NW, Biesinger B, Fleckenstein BW, Desrosiers RC, Identification of transforming genes of subgroup A and C strains of Herpesvirus saimiri, Proceedings of the National Academy of Sciences (USA), 88(16), 7051-5, August 1991
  • Docherty JJ, Dobson AT, Trimble JJ, Jennings BA, Herpes simplex virus type 1 that exhibits herpes simplex virus type 2 sensitivity to (E)-5-(2-bromovinyl)-2'-deoxyuridine, Intervirology, 32(5), 308-15, 1991
  • Trimble JJ, Desrosiers RC, Transformation by herpesvirus saimiri, Advances in Cancer Research, 56, 335-55, 1991
  • Trimble JJ, Regier DA, Desrosiers RC, Herpesvirus saimiri U RNA sequence variation, Nucleic Acids Research, 18(21), 6456, November 1990
  • Biesinger B, Trimble JJ, Desrosiers RC, Fleckenstein B, The divergence between two oncogenic Herpesvirus saimiri strains in a genomic region related to the transforming phenotype, Virology, 176(2), 505-14, June 1990
  • Trimble JJ and Desrosiers RC, Transformation by Herpesvirus saimiri, In: Vande Woude GF and Klein G (eds). Advances in Cancer Research, Academic Press, Inc., New York, 56, 335-351, 1990
  • Murthy SC, Trimble JJ, Desrosiers RC, Deletion mutants of herpesvirus saimiri define an open reading frame necessary for transformation, Journal of Virology, 63(8), 3307-14, August 1989
  • Biesinger B, Grassmann R, Fleckenstein B, Murthy SC, Trimble J, Desrosiers RC, Genes for the synthesis of deoxythymidylate monophosphate in T-cell lymphoma-inducing herpesviruses of nonhuman primates, Current Topics in Microbiology and Immunology, 144, 241-7, 1989
  • Lee SI, Murthy SC, Trimble JJ, Desrosiers RC, Steitz JA, Four novel U RNAs are encoded by a herpesvirus, Cell, 54(5), 599-607, August 1988
  • Trimble JJ, Murthy SC, Bakker A, Grassmann R, Desrosiers RC, A gene for dihydrofolate reductase in a herpesvirus, Science, 239(4844), 1145-7, March 1988
  • Desrosiers RC, Murthy S and Trimble JJ, A Region of the Herpesvirus saimiri Genome Required for Oncogenicity, In: Gallo RG, Haseltine W, Klein G, and zur Hausen H (eds.) Viruses and Human Cancer UCLA Symposia on Molecular and Cellular Biology, New Series. Alan R. Liss, Inc., New York, 43, 309-317, 1987
  • Trimble JJ, Gay H, Docherty JJ, Characterization of the tumor-associated 38-kd protein of herpes simplex virus type 2, The Journal of Reproductive Medicine, 31(5 Suppl), 399-409, May 1986
  • Docherty JJ, Trimble JJ, Roman SR and Naugle F, Incidence of herpes simplex virus type 2 in oral lesions of college students, Journal of Medical Virology, 16, 283-287, 1985

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